Greenfield is a city in Greene County, Illinois, United States. The population was 1,059 at the 2020 census. Greenfield is located in ea…Greenfield is a city in Greene County, Illinois, United States. The population was 1,059 at the 2020 census. Greenfield is located in eastern Greene County at 39°20′35″N 90°12′35″W / 39.34306°N 90.20972°W. Illinois Route 267 passes through the city, leading north 27 miles to Jacksonville and south 13 miles to Medora. Carrollton, the Greene County seat, is 13 miles to the southwest via Routes 267 and 108.
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