La Salle is a city in Watonwan County, Minnesota, United States. The population was 79 at the 2020 census. La Salle was platted in 1899, …La Salle is a city in Watonwan County, Minnesota, United States. The population was 79 at the 2020 census. La Salle was platted in 1899, and named for René-Robert Cavelier, Sieur de La Salle, a French explorer of North America. A post office has been in operation at La Salle since 1900.