Santo Domingo, officially the Municipality of Santo Domingo, is a municipality in the province of Ilocos Sur, Philippines. According to the 2020 census, it has a population of 29,041 people. The name of the municipality came from its old moniker, "Paggappuan ti Santol iti Domingo," an Ilocano term meaning "The source of the Santol sold every Sunday." Santol is the name of the tree bearing round, yellowish fruits growing in abundance in the municipality, notably in Barangay Pussuac.
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