Cartagena is a Chilean commune located in the San Antonio Province, Valparaíso Region. The commune spans an area of 245.9 km². In th…Cartagena is a Chilean commune located in the San Antonio Province, Valparaíso Region. The commune spans an area of 245.9 km². In the seventeenth century the area surrounding the town became a major producer of wheat, which was shipped to Peru and Spain via the port of Cartagena.