A common in the field is that the tropism of a particular AAV serotype can differ across species. AAVs engineered to target particular cells following systemic delivery in mice, for instance ...

Underpinning Voyager’s mission is its trademark AAV capsid-discovery platform, Tropism Redirection of AAV by Cell-type-specific ... the naturally occurring AAV serotype that is currently ...

In general, base editing induces genetic modifications without relying on double-strand breaks (DSB), resulting in healthier cells that are ... selection of AAV serotype, route of administration ...

By contrast, in AAV patients, neutrophil surface SEMA4D is shed by ADAM17. Soluble SEMA4D had pro-inflammatory functions on endothelial cells. In addition, alteration of the SEMA4D-plexin B2 ...