The number of chromosomal alterations observed in AML [2,3] (more than 200 translocations, in addition to several point mutations) is enormous and makes it impossible to screen each one of them as ...

The CD34+CD38− cells, isolated from acute myeloid leukemia (AML), were shown to ... with the relative quiescence of stem cells, and chromosomal aberrations and mutations of leukemic cells.

A new case report was published in Volume 16 of Oncotarget on February 5, 2025, titled “A case report of donor cell–derived ...

AML tends to harbor fewer mutations than solid tumors, making it challenging to infer clonal structure. Here, we present a 9-year, whole-exome sequencing study of a single case at 12 time points ...

AML: Acute myeloid leukemia; APL: Acute promyelocytic leukemia; CBF: Core-binding factor; CEBPA-DM: CCAAT enhancer-binding protein-α with double mutation; CN-AML: Cytogenetically normal AML.

In January 2025, Aptose announced the initiation of the TUSCANY trial and dosing in the first cohort of newly-diagnosed AML patients with the lowest starting dose (40 mg) of TUS as part of the ...

Mutations in the p53 gene (TP53 ... of p53 dysfunction mentioned on our p53 tumor suppressor network page, CK AML is defined by the presence of three or more detectable chromosomal abnormalities that ...

Laboratory analyses showed that the patient who developed AML had significant chromosomal abnormalities and mutations in the RUNX1 and PTPN11 genes typically associated with the development of the ...

According to doctors, AML happens due to mutations in certain genes or chromosomes. There are several AML subtypes, all of which can affect your blood cell levels, but have different symptoms and ...

controlled trial enrolled 153 people aged 55 years and above with r/r AML and those who were heavily pre-treated and had high ...