Genomic Interrogation of Secondary-Type Acute Myeloid Leukemia: Response and Outcomes to Contemporary Therapies,” published in the February 2025 issue of American Journal of Hematology by Senapati et ...

The CD34+CD38− cells, isolated from acute myeloid leukemia (AML), were shown to ... with the relative quiescence of stem cells, and chromosomal aberrations and mutations of leukemic cells.

A new case report was published in Volume 16 of Oncotarget on February 5, 2025, titled “A case report of donor cell–derived ...

Mutations in the p53 gene (TP53 ... of p53 dysfunction mentioned on our p53 tumor suppressor network page, CK AML is defined by the presence of three or more detectable chromosomal abnormalities that ...

studied hundreds of patients with acute myeloid leukemia (AML). They discovered that specific mutations in the STAG2 protein ...

Laboratory analyses showed that the patient who developed AML had significant chromosomal abnormalities and mutations in the RUNX1 and PTPN11 genes typically associated with the development of the ...

Here we validate this hypothesis, demonstrating the efficacy of the BET inhibitor I-BET151 across a variety of AML subtypes driven by disparate mutations. We demonstrate that a common ‘core ...

In January 2025, Aptose announced the initiation of the TUSCANY trial and dosing in the first cohort of newly-diagnosed AML patients with the lowest starting dose (40 mg) of TUS as part of the ...

It is worth noting that gross chromosomal abnormalities can only be detected in a proportion of leukemia (e.g., in approximately 55% of AML). When metaphase cytogenetic analysis is applied to the ...

According to doctors, AML happens due to mutations in certain genes or chromosomes. There are several AML subtypes, all of which can affect your blood cell levels, but have different symptoms and ...