CHICAGO – A new gene expression atlas developed using single ... bulk RNA sequencing data from more than 1,200 AML patient samples, they estimated the abundance of each leukemia cell state ...

Therapeutic efforts in acute myeloid leukemia (AML) face persistent challenges due ... disruptions follow shared patterns or are unique to each mutation. Single-cell RNA sequencing (scRNA-seq) offers ...

we’ve not only advanced our understanding of how differentiation goes awry in AML, but we’ve also provided an accessible toolkit for other researchers to rapidly map and classify their own blood ...

A comprehensive map of aberrant hematopoiesis in people with acute myeloid leukemia defines specific cell states and ...

Here we use a human model AML system ... progenitor cells. The rationale was that if we could generate multiple AMLs from a single donor, and if we performed RNA/Exome sequencing on the initial ...

Singleron Biotechnologies today announced the launch of MobiuSCOPE, a single cell RNA sequencing kit that provides full-length transcript analysis using standard short-read sequencing. Founded in 2018 ...

Led by Ryan Flynn, MD, PhD, assistant professor of stem cell ... one RNA-binding protein on the cell surface, NPM1, as a potent selective target for treating acute myeloid leukemia (AML) as ...

DOI: 10.1016/j.cell.2025.01.040 Treatment of acute myeloid leukemia models by targeting a cell-surface RNA-binding protein, Nature Biotechnology (2025). DOI: 10.1038/s41587-025-02648-2 ...

We offer a range of services, including single cell RNA sequencing and spatial transcriptomics. Our facility is equipped with state-of-art instruments, including the 10X Genomics Chromium X which ...

Therapeutic efforts in acute myeloid leukemia (AML ... follow shared patterns or are unique to each mutation. Single-cell RNA sequencing (scRNA-seq) offers more precise insight into cancer ...