Beta-globin gene: 2 copies (1 from each parent) located on chromosome 11 To develop alpha-thalassemia disease, you’d need to inherit three or more faulty alpha-globin genes.

The condition of mice with a genetic blood disease called beta-thalassemia improved significantly following treatment of their blood forming cells with a gene that enabled them to produce the type ...

It occurs as the result of a point mutation or less commonly, a deletion in the gene that codes for the beta chain, on chromosome 11. It occurs in 1 of 10,000-100,000 people, depending on the ...

Patients with transfusion-dependent beta-thalassemia who received betibeglogene autotemcel achieved durable transfusion independence with near-normal hemoglobin levels, according to study results ...

But humans have another hemoglobin subunit gene (gamma-globin), which is expressed during fetal development instead of beta-globin. Gamma-globin combines with alpha-globin to form fetal hemoglobin.

But humans have another hemoglobin subunit gene (gamma-globin), which is expressed during fetal development instead of beta-globin. Gamma-globin combines with alpha-globin to form fetal hemoglobin.

But humans have another hemoglobin subunit gene (gamma-globin), which is expressed during fetal development instead of beta-globin. Gamma-globin combines with alpha-globin to form fetal hemoglobin.

Abstract P1436: Development of a Beta-Globin Gene Replacement Strategy as a Therapeutic Approach for Beta-Thalassemia Presenting Author: Beeke Wienert, Ph.D., associate director, gene engineering ...

Long-term follow-up data showed betibeglogene autotemcel to be a safe and efficacious treatment for patients with transfusion-dependent beta-thalassemia, according to study results presented at ...

Current lentiviral vectors all contain the human beta-globin gene along with its promoter, 3 so-called hypersensitive sites that are important for gene transcription, and a truncated version of ...

The modified cells make up just 1 in 9 of P2’s collection, and the fixed beta-globin molecules are just a third of this total. Neither is in the majority, but they’re enough to ensure that he ...