These data point to a novel mechanism of action for the CAIX-mediated stimulation of MMP14 activity whereby CAIX enhances MMP14 activity by increasing the rate of proton transfer required for ...

which is also the point where carbonic anhydrase activity is concentrated. These insights led the authors to propose a new "lock and trigger" model for spider silk formation, in which gradual ...

The un-linked polymers were mixed with photoinitiators and a solution of carbonic anhydrase and extruded through a fine nozzle with a syringe pump. The resulting thread was blasted with 280–450 ...

How does acetazolamide work (mechanism of action)? Acetazolamide blocks an enzyme called carbonic anhydrase in the body. This helps lower pressure inside the eye, increases how much you pee to ...

when they discovered a previously unknown function of an enzyme called carboxysomal carbonic anhydrase (CsoSCA). The enzyme, it turns out, allows the algae to suck more carbon dioxide out of the ...

"Modified carbonic anhydrase activity may be a pathophysiological mechanism in OSA," said Hedner. Sulthiame, a carbonic anhydrase inhibitor, showed safety and effectiveness for improving OSA in a ...

Some of the mechanisms of the different diuretics are described below: These drugs inhibit the enzyme carbonic anhydrase, which has the effect of decreasing the reabsorption of bicarbonate in the ...

Chronic kidney disease and the risk of incident renal and urothelial cancer in a population-based cohort of 1.2 million adults. Background: No biomarkers have been routinely utilized to provide ...

Carbonic Anhydrase IX Expression, a Novel Surrogate Marker of Tumor Hypoxia, Is Associated With a Poor Prognosis in Non–Small-Cell Lung Cancer. JCO 21 , 473-482 (2003). DOI: 10.1200/JCO.2003.11.132 ...