Chromosomal instability plays a crucial role in the ... developed in connection with the activation of the Ras signaling pathway, against which new classes of drugs are currently being developed ...

Identifying targetable pathways linked to chromosomal instability is exciting, as it creates an opportunity to therapeutically intervene to tackle a feature of cancer that was hitherto considered ...

Two types of elements contribute to instability leading to rearrangements: suppressors, which function in trans and include replication, repair and S-phase checkpoint factors; and chromosomal ...