In all the 13 NBS heterozygotes analysed, we found spontaneous chromosome instability consisting in ... antibodies directed against nibrin. After 1 h incubation with an anti-rabbit secondary ...

According to Johns Hopkins Medicine researchers, their recent study may upend a long-held theory of chromosome ... with short telomere syndromes, not chromosomal instability.

In these circumstances, the DNA cannot replicate itself naturally, generating replication stress, mutations and chromosome mutations. Genome instability is the main risk factor in the development ...

Johns Hopkins Medicine scientists say their 20-year study of more than 200 people with premature aging syndromes caused ... short telomeres with instability of chromosomes, the X-shaped structures ...

Some of these copy number variations (CNVs) are associated with disease, as with schizophrenia, wherein rare CNVs on chromosomes, including 1, 15, 16, and 22 ... genetic defects can cause the same ...

Oncotarget published "Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells" which reported that this assay is based on the use of two isogenic ...

The impact of clonal size on the revised international prognostic scoring system (R-IPSS) in myelodysplastic syndromes (MDS) with a single cytogenetic abnormality. Effect of enforced expression of ...

The paper S.F. Bakhoum et al., “Chromosomal instability drives metastasis through a cytosolic DNA response,” Nature, 553:467-72, 2018. Aneuploidy—the presence of abnormal numbers of chromosomes in a ...

We recently reported expression (CINSARC; Complexity Index in Sarcoma) and Genomic Index prognostic signatures related to chromosome integrity in sarcomas ... and children are associated with genome ...