Standard curves were constructed using serial twofold dilutions of genomic DNA from an individual without 1q21.1 copy number variation and used to estimate amounts of DNA in the experimental ...

Thanks to engrained lessons from cytogenetics, researchers largely regarded variations in gene copy a rarity ... his team were running two normal DNA controls for a cancer genome study, and "copy ...

April 1, 2007 (Vol. 27, No. 7) High-Resolution Oligo Arrays for Research and BAC Arrays for Growing Diagnostics Sector High density, oligonucleotide-based array-Comparative Genomic Hybridization ...

Second, the coefficient of variation of sequence reads for each chromosome modulates the effect of the size of copy-number variants on the probability of false positive results. For example ...

With the human genome complete, one of the more prominent follow-up projects has been the cancer genome ... they look for copy number variations, in which larger segments of DNA are either ...

Study results demonstrate that combining copy number variation (CNV) information with cfDNA fragment size information could serve as a new avenue for early detection of colorectal cancer ...

Copy number variation, a major cause of structural variation in the genome, plays an important role in human disease. Determination of copy number variation requires both precision and accuracy.

To capture the gene’s proline-, threonine-, and serine-rich tandem repeat copy number variations ... is a good example of such variation in the types of functional CNVs and a primary focus ...

Gene Duplications Give Clues to Humanness: All told, the researchers found more than 4000 genes that showed lineage-specific changes in copy number, with the numbers steadily increasing over ...

November 9, 2009 (Honolulu, Hawaii) — Finnish researchers have identified several copy-number variations (CNVs ... occurred with large deletions. For example, 10% of deletion carriers were ...