The actions of the cortisol-synthesis inhibitors must be considered in the context of the metabolic pathways involved in steroid biosynthesis (Fig. 1). Metyrapone decreases cortisol production ...

In addition to CYP11B2, cells later in the cell-fate pathway also expressed more CYP17A1, which contributes to cortisol ...

Furthermore, metabolic factors including insulin and obesity-related signals may play a role in the regulation of both enzymes involved in the steroidogenetic pathways, as well as in the ...