Neuropsychiatric disorders are becoming increasingly prevalent. Given their complex and multifactorial pathogenesis, there is ...

This study identifies 47,350 enhancers active in human neurons during differentiation and links some to genes involved in ...

New research from the Furlong group at EMBL Heidelberg has identified a shift in how genes are regulated by DNA control ...

MaizeCODE is a genomic project analyzing the genetic basis of maize domestication. Researchers identified key regulatory ...

RNA polymerase binds to a region just before the gene, called the promoter, before moving down the DNA to the gene. Enhancers are regions of DNA that act as molecular switches for turning genes on ...

Enhancers can be thousands of nucleotides away from the promoters with which they interact, but they are brought into proximity by the looping of DNA. This looping is the result of interactions ...

Neuropsychiatric disorders are becoming increasingly prevalent. Given their complex and multifactorial pathogenesis, there is an urgent need for ...

Enhancers were formerly believed to be modular. Each enhancer occupies a separate region of DNA, as the term suggests. “We have shown, however, that this is not absolutely true," explained ...

“We didn’t think it would work.” The results serve as an extreme example of what scientists are now recognizing as trends among enhancers—that activity can be conserved over long evolutionary ...

Large consortia-led projects such as ENCODE (Encyclopedia of DNA Elements) have made great strides in identifying various functional elements of the genome. These include enhancers, activators, and ...

Enhancers, which boost gene transcription ... accurate and efficient in predicting the regulatory activity of any DNA sequence. Its predictions align closely with experimental results, performing ...