UCLA Health researchers say study findings uncover Huntington's disease mechanisms and pave new ways to develop treatments.

A new paper, published today in Science, identifies widespread differences between DNA sequences and their corresponding RNA transcripts in human cells, and demonstrates that these differences result ...

Scientists have identified strains of one of the world's most dangerous fungal pathogens, already resistant to our most effective antifungal drugs, which are also five times more likely to acquire ...

Intriguingly, these regions contain multiple genes involved in repairing DNA mismatches. However, the mechanistic connections ...

This protein machinery—the DNA mismatch repair system—reversed the prime editor’s changes if it noticed the rewriting. By adding in silent mutations near the edits they made to F508del, Liu’s team ...

Together with Tabrizi’s study, the findings converge on the idea that MSH3 and other DNA mismatch repair enzymes accelerate CAG expansion, and thus degeneration, in HD-vulnerable neurons. Both Tabrizi ...

the MMR hMSH2–hMSH6 heterodimer provides an important DNA damage signal for colorectal, endometrial and ovarian cells, and mutations in either of these genes leads to ineffective mismatch repair ...

DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce ...