research suggests that certain dopaminergic pathways may also be important in relieving depression-like symptoms. Research in humans has demonstrated that for some individuals with treatment-resistant ...

The ASCEND trial evaluated the safety, tolerability, and efficacy of solengepras and aimed to establish its potential to ...

The pivotal, Phase III study will evaluate the change in average daily “OFF” time in solengepras patients compared to placebo ...

Almost immediately, however, it was clear that dopamine and its associated signaling pathways were far from straightforward. Once animals learned that a certain cue predicted a certain reward, these ...

Finally, investigators treated the dopaminergic neurons with lipoic acid ... Krainc and his collaborators will continue to study this metabolic pathway in other forms of Parkinson's disease.

A new Drosophila collection of Parkinsonism models reveals early synaptic cholinergic projection neuron dysfunction, linking synaptic failure to later dopaminergic decline, highlighting a role for ...

This investigational treatment was generally well tolerated with no serious adverse events; fewer adverse events related to non-motor symptoms were reported in the solengepras arm Pivotal Phase 3 ...

in particular those associated with the nigrostriatal dopaminergic pathway. There is now robust experimental evidence for a neuroprotective effect of nicotine upon dopaminergic neurons.