Quinidine, disopyramide, procainamide, sotalol, dofetilide, ibutilide and amiodarone can potentially prolong the QT interval. The antiarrhythmic drugs that do not prolong the QT interval include ...

A prolonged QT interval has a variety of causes and can be a very serious ECG finding, as it may lead to the potentially fatal arrhythmia polymorphic ventricular tachycardia (Torsades de Pointes).

Mechanisms of Q-Tc Interval ... Q-Tc interval prolongation was due to direct inhibition of cardiac ion channels or disruption of hERG potassium channels. Though these drugs had little direct ...

Possible neurotoxicity with lithium: monitor, discontinue if occurs. Caution with drugs that prolong the QT interval (eg, Class 1A [eg, procainamide, quinidine, disopyramide] or Class 3 ...

Possible neurotoxicity with lithium: monitor, discontinue if occurs. Caution with drugs that prolong the QT interval (eg, ketoconazole, paroxetine). May be potentiated by CYP3A4 inhibitors ...

Contributing to its lack of identification is the fact that individuals may or may not show QT prolongation ... that many drugs can affect the QT interval and put the patient at risk for a ...

Many drugs, including hydroxyzine ... or taking certain medicines that can affect the QT interval. People with prolonged QT intervals should not take hydroxyzine. Also, people with these risk ...

A significantly prolonged QT interval increases the risk of arrhythmias ... Patients should consult their doctors about alternative medications that have a lower impact on heart rhythm.