Ubiquitin and other ubiquitin-like molecules (UBLs) are post-translationally attached to proteins through a sequential enzymatic cascade that uses an E1 activating enzyme, an E2 conjugating enzyme ...

E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme) and E3 (ubiquitin-ligating enzyme), acting as a substrate-recognition molecule 11,12. A link between Parkinson disease and the ...

“Our innovative approach to targeted protein degradation via the ubiquitin-conjugating enzyme (E2) family represents a breakthrough in drug development, allowing us to address previously ...