UM171-driven LHC subunit degradation is mediated by a CRL3 family E3 ligase adaptor KBTBD4, but the direct target of UM171 was unclear. In the first paper, Yeo et al. showed that UM171 could ...
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Developing a simple, cost-effective method to identify the targets of a crucial protein-modifying enzymeMapping the human E3 target protein landscape can help us ... between the kinase family of proteins and the ubiquitin ligase family," said Sagar Bhogaraju, Group Leader, EMBL Grenoble.
However, the power of PROTACs lies in the engagement of E3 ligases, and currently, less than two percent of the vast array of E3 ligases in the human genome have been explored in the TPD field. Dr.
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