AceLink is advancing a small-molecule treatment option for Fabry disease, which could provide a more convenient alternative ...

Fabry disease is an X-linked lysosomal storage disorder caused by a deficiency of the enzyme α-galactosidase A (GLA), which leads to complex multisystemic involvement, with the majority of patients ...

It remains to be seen whether other enzyme-replacement therapies can duplicate its economic success. Fabry's disease is an X-linked disorder caused by a deficiency of α-galactosidase. The ...

and then carefully construct an experiment to measure the catalytic turnovers of their test enzyme, β-galactosidase. Though many groups including Xie's had attempted to use fluorescence to study ...