A new study reveals how AI-driven deep learning models can decode the genetic regulatory switches that define brain cell ...

Gene regulation in our cells—the decision on which proteins are produced for the various processes of the cell—is strictly ...

Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called enhancers, was thought to have its own place on the DNA. Different enhancers ...

Previously, researchers thought that microRNA was a kind of useless residue in cells and blood. But these tiny threads are ...

Researchers uncover key mechanisms in gene regulation that may lead to better design of RNA-based medicines.

The turning on of this single gene results in an apparent freak of nature. Mice whose agouti gene is "on" are also more likely to suffer from diabetes and cancer as adults. The implications of ...

Genome-wide association studies (GWASs) have linked genetic variants to neuropsychiatric disorders, but their regulatory roles in non-coding regions remain largely unclear. Using the LUHMES neuronal ...

In addition, the use of tools like lentiMPRA and MPRALegNet will help to better equip researchers to unravel the complexities of gene regulation and to explore the vast, uncharted territories of ...

In a new study published in Science, a Belgian research team explores how genetic switches controlling gene activity define brain cell types across species.

In 2019 an international team of researchers identified 109 genes that were associated in different combinations with eight ...

“It was probably in about 2015 that we started working on the idea of more of a designer gene repression loop,” said Nicole Becker, a molecular biologist at the Mayo Clinic and study coauthor. In the ...

Although a woman's ovaries produce the most estrogen, various types of estrogen are also synthesized throughout different tissues in the body, including the brain's neurons.