Medically reviewed by Lindsay Cook, PharmD Irritable bowel syndrome with constipation (IBS-C) is characterized by symptoms ...

Mononuclear cells express enzymes involved in the NO/cyclic guanosine monophosphate (cGMP) generating system, as well as PDE5. The objective of the study was to determine the effect of sildenafil ...

Bone growth occurs through the proliferation of specialized cells of the cartilage tissue, known as chondrocytes, on either end of a bone. This process requires the synthesis of extracellular matrix ...

Host defenses rely on innate immunity, a rapid response based on pattern recognition, and adaptive immunity, a more slowly developing specific antigen-recognition system. This review summarizes fea ...

The CNP-bound receptor activates a molecule, cyclic guanosine monophosphate (cGMP), which in turn activates protein kinase G (PKG) that phosphorylates a membrane ion channel.