Key steps in the life cycle of HCV include entry into the host cell, uncoating of the viral genome, translation of viral proteins, viral genome replication, and the assembly and release of virions.

Using sophisticated single-cell analysis techniques and whole genome sequencing, the researchers analyzed the immune cells in the blood of four patients with HCV-triggered cryoglobulinemic vasculitis.

Finally, although HCV is an RNA virus that does not produce DNA replication intermediates that can integrate into the host genome, it still manages to persist in most cases (usually for life in ...

are able to detect an HCV-RNA-positive strand at a sensitivity below 10 virus genome equivalents (vge) and a replicative HCV-RNA-negative strand at 25 - 50 vge/reaction or per 1 µg of total RNA.

The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...

With evidence of prolonged human engraftment, we next infected mice with serum from HCV-infected human donors. We transplanted non-infected human hepatocytes into 27 offspring from heterozygous ...

The hepatitis D virus-like genome discovered in the duck samples also had an open reading frame with the capacity to express an 185-amino-acid-long protein. The location of this open reading frame ...