In vivo studies using embryonic Foxn1-deficient thymic epithelium lacking hematopoietic ... further enables proT-cell differentiation from both mouse and human blood stem cells.

Stem cells can produce any other cell type, it is just a matter of telling them in the right way. From a biological ...

Allogeneic hematopoietic stem-cell (HSC) transplantation (HSCT ... the donor HSCs must have both self-renewal and multipotential differentiation capabilities, or “stemness,” to continually ...

New findings support a model of blood cell differentiation in which the production of red blood cells is the default fate of hematopoietic stem cells, which can also produce platelets and white ...

The process by which hematopoietic stem cells give rise to mature ... development of a model of hematopoietic differentiation that focuses on red blood cells as the default pathway for all myeloid ...

During development, the differentiation of stem cells is ... Tracking clusterin expression in hematopoietic stem cells reveals their heterogeneous composition across the lifespan, Blood (2025).

This process is called differentiation ... tissue in the same area in which they are found. For example, hematopoietic stem cells are a type of adult stem cell found in bone marrow.

Although murine hematopoietic stem cells are largely quiescent ... turn off self-renewal genes and turn on differentiation genes. As cells differentiate, the number of differentiation genes ...

Led by Lars Velten, PhD, group leader at the CRG, the study designed enhancers with specificity to user-defined combinations of hematopoietic ... In blood stem cell differentiation, single-cell ...

This myeloid/platelet-biased differentiation disrupts normal ... Currently, Dr. Iwama’s lab is focused on aging of hematopoietic stem cells and aged-associated hematological malignancies.