Figure 1: Oncogene Her2/neu-initiated, Akt-mediated p21 Cip1/WAF1 inactivation as a suppressor of tumour growth and the cell cycle.

as demonstrated by the lack of effect on AKT phosphorylation in trastuzumab-treated cells but reduced phosphorylation in response to lapatinib. Levels of HER2 protein did not correlate with ...

In a subgroup of patients with AKT-positive tumours – around half of ... physician's choice of chemotherapy in patients with HR+/HER2- advanced breast cancer that had progressed after endocrine ...

Internalization and degradation of HER2 receptor protein Western blot showed ... increased cell signaling from other HER receptors, increased Akt activity, reduced PTEN level, reduced p27kip1 ...

The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways ... We have shown that tumors with HER2 amplification or PI3K mutation ...