Germline and somatic sequence ... mutations in non-coding regions as these sequences have yet to be explored to the same extent as coding genes owing to the lower costs of exome sequencing and ...

Most genetic studies choose to focus purely on the exome – the small ... "We place a gene there, put a non-coding sequence just in front of it, and another one far away, and see how this ...

This research represents a “real-world” case in human genetics and provides strong evidence that targeted sequencing ... The human exome is comprised of the most functionally relevant 1% of the human ...

using whole-exome sequencing (WES) data from libraries created on a fully automated liquid handler as an example; An introduction to how the Roche Bioinformatics Team works internally to develop new ...

We benchmark allele-specific CNA analysis performance of whole-exome sequencing ... tumor-only sequencing, especially in diagnostic settings. Furthermore, implementation of the workflow on Terra will ...

For their newly reported study, the team carried out an exome-sequence genome-wide association study (GWAS) for LOY, to evaluate the role of rare protein-coding variations. “Previous genetic ...

To examine intratumor heterogeneity, we performed exome sequencing ... from surgery until tumor progression. Figure 1 shows biopsy and treatment timelines. Exon-capture sequencing was performed ...

Respiratory toxicities after concurrent chemoradiotherapy and subsequent consolidation immune checkpoint inhibitors in locally advanced non-small cell lung cancer: Infectious and non-infectious ...