Heat-shock protein 90 (Hsp90) inhibitor downregulates c-Myc expression and upregulates the expression of tumor repressor proteins such as p53 and pRB, inhibiting the G1/S transition and causing G2 ...

We determined the structure and function of Heat Shock Protein 90 (Hsp90), a molecular chaperone which is critical for the growth and survival of cancer cells. We worked with partners to discover the ...

To test this, the researchers injected the Hsp90 inhibitor KU-32 into the spinal cord of mice prior to morphine treatment and then exposed the animals to the tail-flick test, an established pain model ...