Huntington’s disease arises from a genetic mutation that results in an abnormal expansion of the CAG trinucleotide sequence ... (HTT) gene. This mutation causes the huntingtin protein to develop ...

This debilitating, heritable condition is caused by >35 repeats of a trinucleotide sequence—a CAG repeat—in the Huntington (HTT) gene. The resulting mutant HTT protein elicits many toxic ...

Aggregation of huntingtin protein with an expanded ... in which a short sequence element modulates the speed of aggregation of pathogenic Htt, provides a new drug target for prevention of aggregation.

HD is caused by an expanded glutamine repeat in the N-terminal region of the huntingtin (HTT) protein. The disease onset has distinct patterns in juvenile and adult patients, but with similar disease ...