Area and diameter of islets were measured using the AxioVision 3.1 software. Human islets were fixed in Bouin solution or Shandon Zinc Formula-Fixx (Anatomical Pathology International, Runcorn ...

Recently published 3D human and rat “pseudo-islets” display long-lived, robust metabolic activity, offer convenient solution for islet transplantation, anti-diabetic drug development, and assessment ...

One significant advancement is the development of pancreatic islets derived from human pluripotent stem cells (hPSC-islets). These stem-cell-derived islets have shown promise in treating diabetes ...

More information: Esra Karakose et al, Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors, Cell Reports Medicine (2024). DOI: 10.1016/j ...

first-in-human study transplanting UP421, an allogeneic primary islet cell therapy engineered with Sana’s hypoimmune (HIP) technology, into a patient with type 1 diabetes without the use of any ...

First-in-Human Study Provides Evidence that Sana’s Hypoimmune (HIP) Technology Enables Transplanted Islet Cells to Avoid Immune Rejection and Produce Insulin Without Immunosuppression Results ...