An improved understanding of the structure and the function of the huntingtin protein could contribute to the development of new treatment methods in the future.

Determining the three dimensional structure of the huntingtin protein could help develop new treatments for Huntington's disease.

Mutations on a single gene, the huntingtin gene, are the cause of Huntington's disease. They lead to an incorrect form of the correspondent protein. With the help of cryo-electron microscopy, ...

A research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative disorder known as Huntington's Disease. Using genetic ...

This now enables its functional analysis. An improved understanding of the structure and the function of the huntingtin protein could contribute to the development of new treatment methods in the ...

However, as huntingtin protein is required for the development and normal function of the brain, it is critical to specifically eliminate the disease-causing protein while maintaining the ones ...

Mutations on a single gene, the huntingtin gene, are the cause of Huntington's disease. They lead to an incorrect form of the correspondent protein. With the help of cryo-electron microscopy ...

Researchers have revealed new clues to how a defective form of the huntingtin protein may cause the deadly changes that lead to Huntington's disease -- by potentially disrupting the process of ...

In this paper, the authors show that, in the non-diseased state, the huntingtin protein promotes homotypic interactions between neuroepithelial cells, a process that is critical for proper ...

Loss or modulation of normal huntingtin function in response to polyQ repeat expansion might also have a role in Huntington disease 35.

The huntingtin protein may travel together with important signaling molecules in injured neurons, researchers find.

To try to understand this normal function, joint first authors Eliana Romero, Guang-Ho Cha, and Patrik Verstreken created the first fly model of HD that expresses the full-length human huntingtin ...