Also for this reason, it is important to learn more about the function of the healthy huntingtin protein. Kochanek confidently looks into the future: "The decoded structure will bring us a big ...

Mutations on a single gene, the huntingtin gene, are the cause of Huntington's disease. ... we still know relatively little about the function and tasks of the healthy protein," explains Kochanek.

A research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative disorder known as Huntington's Disease. Using genetic ...

Also for this reason, it is important to learn more about the function of the healthy huntingtin protein. Kochanek confidently looks into the future: “The decoded structure will bring us a big step ...

This now enables its functional analysis. An improved understanding of the structure and the function of the huntingtin protein could contribute to the development of new treatment methods in the ...

Mutations on a single gene, the huntingtin gene, are the cause of Huntington's disease. They lead to an incorrect form of the correspondent protein. With the help of cryo-electron microscopy, ...

Huntington disease is devastating to patients and their families — with autosomal dominant inheritance, onset typically in the prime of adult life, progressive course, and a combination of motor ...

Huntingtin (htt) is the 3,144 amino acid protein encoded by Hdh (also known as Htt). Hdh contains a polymorphic tri-nucleotide CAG repeat that is translated into polyglutamine amino acid (polyQ ...

Researchers have revealed new clues to how a defective form of the huntingtin protein may cause the deadly changes that lead to Huntington's disease -- by potentially disrupting the process of ...

This research, titled, “A pathogenic-proteolysis resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function”, co-authored by Hyeongju Kim, was published ...

HD flies with one copy of the synaptic vesicle proteins Snap, syntaxin1A, or the syntaxin-associated protein Rop all showed normal synaptic activity. The same mutations also suppressed ...

BUFFALO, N.Y. — In a new University at Buffalo-led study, scientists propose a new role for the huntingtin protein (HTT), which causes Huntington’s disease when mutated. A team led by UB biologist ...