Previous studies have shown that IL-15 is critical to the induction of T-cell large granular lymphocyte (T-LGL) leukemia. A Phase I trial of a humanized antibody (Hu-Mikβ1) to the IL2/IL15Rβ ...
Hu-Mikβ1 is a humanized antibody to the IL-2/IL-15Rβ receptor and was shown to block IL-2- and IL-15-driven cell proliferation in preclinical models and patient leukemic cells. Hu-Mikβ1 was ...
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