"In the inflammatory cascade, h15-LOX-2 is one of the few enzymes ... The enzyme is involved in the biosynthesis of ...

Drugs that target the proinflammatory mediator IL-1 ... need to better understand where IL-1 is positioned in the cascade of inflammatory response. It is possible that IL-1 may directly mediate ...

Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid mediators exert ... form and unleashing a cascade of downstream ...

These therapies target specific inflammatory mediators or pathways that are felt ... arresting the inflammatory cascade responsible for the clinical features of a disease, while avoiding the ...

These mediators, which include chemicals such as histamine, cause an inflammatory cascade. This cascade recruits white blood cells that cause swelling, smooth muscle constriction, and increase ...

SPMs are lipid mediators that may drive the resolution of airway inflammation by reducing proinflammatory signals and enhancing immune defense. Researchers recruited patients from the London COPD ...

A number of these inflammatory mediators, such as IL-10, IL-6, TGF-β, and TNF-α, have been proven to participate in chronic inflammatory-associated tumor progression. The presence of high levels ...

Jacobson followed this abnormal RAS in the lung fluid samples to the kinin cascade, an inflammatory pathway that is tightly regulated by the RAS. He found that the kinin system—in which a key peptide, ...