Medscape11d
Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity
A meaningful rank of NSAIDs in terms of inhibition of COX should take into account the complexities inherent in biochemical systems, including the mechanism of catalysis of the endogenous substrate.
Monthly Prescribing Reference1y
Ibuprofen/famotidine
The mechanism of action of the ibuprofen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Famotidine is a competitive inhibitor ...
Monthly Prescribing Reference7y
Indomethacin Suppositories
The mechanism of action of indomethacin, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Use lowest effective dose for shortest ...
Nature1mon
Cyclopentenone prostaglandins—new allies in the war on inflammation
Inhibition of these activities is responsible for most of the side effects of NSAIDs. NSAID research changed radically with the discovery that COX existed in two isoforms: the constitutively ...
Ärzteblatt4y
Salicylate Intolerance – Pathophysiology, Clinical Spectrum, Diagnosis and Therapy: Some Additional Comments
Dtsch Arztebl 2007; 104(46): A 3178–83. 2. Frölich JC: A classification of NSAIDs according to the relative inhibition of cyclooxygenase isozymes. Trends Pharmacol Sci 1997; 18: 30–4.
Medscape1mon
Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity
All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...