ErbB3/HER3 intracellular domain is competent ... et al. A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor ...

The structure led to a surprising discovery: The drug binds simultaneously at two distinct positions of the receptor—one copy bound at an extracellular site and the other at the intracellular one.

The crystal structure of a second G protein ... of seven transmembrane helices connected by extra- and intracellular loops. The receptor fold is very similar to that of rhodopsin in its inactive ...