Game status: Isaac Guerendo is ACTIVE for Week 15 against the Rams. The San Francisco 49ers host the Los Angeles Rams in a Week 15 Thursday Night Football game that is a must-win for both teams.

Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, Matt Barrows of The Athletic reports. The 49ers' 2024 campaign is over, but the team's season ...

Unfortunately, that didn't prove to be the case. Less than two minutes into the game, San Francisco's third-choice running back Isaac Guerendo suffered a left knee injury after it was twisted at ...

Coach Kyle Shanahan said after Sunday's 47-24 loss to the Cardinals that Guerendo (knee/ankle) likely suffered an MCL sprain and will undergo further testing Monday, Lindsey Pallares of the 49ers ...

San Francisco 49ers Isaac Guerendo was carted off the field Sunday against the Arizona Cardinals. He suffered the injury after a scary tackle during the first series of the game. The 49ers drafted ...

San Francisco 49ers rookie running back Isaac Guerendo's 15-yard rushing score gives the 49ers their first touchdown of their "Sunday Night Football" road game against the Buffalo Bills in Week 13 ...

San Francisco 49ers running back Isaac Guerendo's second touchdown of day gets 49ers to 30-point mark vs. Chicago Bears. Watch highlights from the AFC Championship Game between the Buffalo Bills ...

San Francisco 49ers running back Isaac Guerendo is active on Thursday night against the Los Angeles Rams despite his sprained foot. Guerendo, who was listed as questionable, insists he "feels good ...

San Francisco 49ers running back Isaac Guerendo was forced to exit Sunday's game against the Arizona Cardinals during the first offensive drive. The rookie was carted off the field, and the team ...

San Francisco 49ers running back Isaac Guerendo joined the 49ers "You've Got Mail" podcast presented by Delta Dental to discuss his journey to the pros, the early contributions of the rookie class ...