Game status: Isaac Guerendo is ACTIVE for Week 15 against the Rams. The San Francisco 49ers host the Los Angeles Rams in a Week 15 Thursday Night Football game that is a must-win for both teams.

Curious to know about 49ers RB Isaac Guerendo‘s injury? The standout rookie has drawn attention for his breakout performances on the field and his determination to play despite a recent foot injury.

Trent Williams turns 37 in July and the 49ers options are thin beyond him. Ohio State's Josh Simmons offers a future at ...

Unfortunately, that didn't prove to be the case. Less than two minutes into the game, San Francisco's third-choice running back Isaac Guerendo suffered a left knee injury after it was twisted at ...

San Francisco 49ers Isaac Guerendo was carted off the field Sunday against the Arizona Cardinals. He suffered the injury after a scary tackle during the first series of the game. The 49ers drafted ...

San Francisco 49ers running back Isaac Guerendo is dealing with a hamstring injury and is unlikely to play Sunday at the Miami Dolphins, a source told ESPN's Adam Schefter on Thursday. Guerendo ...

San Francisco 49ers rookie running back Isaac Guerendo's 15-yard rushing score gives the 49ers their first touchdown of their "Sunday Night Football" road game against the Buffalo Bills in Week 13 ...

San Francisco 49ers running back Isaac Guerendo's second touchdown of day gets 49ers to 30-point mark vs. Chicago Bears. Watch the highlights from Super Bowl LIX between the Kansas City Chiefs and ...

Coach Kyle Shanahan said Guerendo (foot/hamstring) will be limited at Thursday's practice, Cam Inman of The San Jose Mercury News reports. As Shanahan projected Monday, Guerendo is returning to ...

San Francisco 49ers running back Isaac Guerendo was forced to exit Sunday's game against the Arizona Cardinals during the first offensive drive. The rookie was carted off the field, and the team ...

San Francisco 49ers running back Isaac Guerendo is active on Thursday night against the Los Angeles Rams despite his sprained foot. Guerendo, who was listed as questionable, insists he "feels good ...