Itch was essential for the termination of tumor necrosis factor receptor signaling by controlling ... and proresolving lipid mediators and pathways. Annu. Rev. Immunol. 25, 101–137 (2007).

The involvement of Itch in multiple signaling pathways and pathological conditions is presently an area of extensive scientific interest. This review aims to bring together a growing body of work ...

intensifying the itch sensation. Exactly how pain signaling pathways join in transmitting itch signals was not at all clear—until it caught the attention of scientists led by Zhou-Feng Chen ...

The pathway by which chemicals cause itching has ... The researchers then looked for the nerve cells that receive the mechanical itch signal from the LTMRs. Among the cells in the dorsal horn ...

If those same kinds of neurons exist in the human spinal cord, and if you could block that molecular signaling pathway, you might stop itch transmission and greatly improve someone’s quality of ...

indicating that NPPB did play a role in the itch-signaling pathway. "Our work shows that NPBB does act on the neurons in the spinal cord, and that it plays an important role in this signaling ...

there’s a fixed pathway that transmits the itch signal. But with chronic itching, many neurons can be turned into itch neurons, including those that typically transmit pain signals. That helps ...

Itch is a protective signal that animals use to prevent parasites ... in mice, a dedicated brain pathway drives the mechanical sensation and is distinct from the neural pathway that encodes ...

Then, they performed additional experiments in mouse models and found removal of IL-3 or GD3 cells, as well as blocking its downstream signaling pathways, made the mice resistant to the itch and ...

This includes itching or hives on the skin ... The team found that this process involves a signaling pathway that works like a line of dominoes to boost the production of certain molecules ...