Discover how the brain's most abundant neurotransmitter, glutamate, is revolutionizing psychiatry and offering new hope for ...

Cichon and his colleagues hypothesized that ketamine deactivated certain neurons by blocking their N-methyl-D-aspartate (NMDA) receptor, which is something the drug was already known to do. To probe ...

Enter psychedelics like ketamine, psilocybin, and MDMA, which are being explored as tools to access and process these buried ...

Ketamine reduces certain nervous system functions by inhibiting normal N-methyl-D-aspartate (NMDA) receptor activity. Normally, NMDA receptors, which are located on the surface of nerve cells ...

Ketamine has received a Hollywood makeover. It used to be known as a rave drug (street name special K) and cat anesthetic. However, in recent years, some doctors have prescribed ketamine to treat ...

Depression that resists traditional treatments may have a surprising new contender: laughing gas. Researchers have discovered ...

Now ketamine, a glutamatergic NMDA receptor antagonist, may provide a mechanism that could link these pathways. Figure 1: A schematic of how ketamine may lead to an overall excitation in the cortex.

Silent synapses are dormant neural connections that hold untapped brain potential. Discover how ketamine, exercise, and other ...

One main class of these drugs, which includes propofol and the ether-derivative sevoflurane, work primarily by increasing the activity of inhibitory GABAA receptors, while a second class that includes ...