Safeguarding intestinal stem cells during aging through balanced signaling
A recent study led by Associate Professor Takuya Yamamoto and Researcher May Nakajima-Koyama has revealed that maintaining a ...
Nature3y
Cell Signaling
For instance, a single second messenger or protein kinase might play a role in more than one pathway. Through this network of signaling pathways, the cell is constantly integrating all the ...
Nature12y
Activation of ERBB Receptors
X. Untangling the ErbB signalling network. Nature Reviews Molecular Cell Biology 2, 127–137 (2001) doi:10.1038/35052073. Zhang X. et al. An allosteric mechanism for activation of the kinase ...
New Publication Highlights Unique Properties of ATI-2138, a Potent and Selective Inhibitor of ITK and JAK3
Data Generated to Date Support Potential for Aclaris’ ATI-2138 to Impact Several Human Inflammatory Diseases -WAYNE, Pa., Feb. 12, 2025 ...
mskcc.org8y
The Neal Rosen Lab: Research Overview
Hsp90 signaling and its inhibition in cancer The evaluation of ... Our recent work has shown that Hsp90 is critical for oncogenic RAF kinase-driven ERK activation. The combination of Hsp90 inhibitors ...
Too Old to Operate12d
Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax.
Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...
EurekAlert!17d
Schematic illustration of Z526's effects on cancer-associated cachexia. (IMAGE)
In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...