We report here the crystal structure of an essential DNA binding domain of the RAG1 catalytic core bound to its nonamer DNA recognition motif.

Researchers have developed a new fluorescent label that gives a clearer picture of how DNA architecture is disrupted in cancer cells. The findings could improve cancer diagnoses for patients.

James Watson and Francis Crick revealed the structure of DNA — the genetic instructions in all living things — 70 years ago in the journal Nature. Watson and Crick could not have succeeded ...

In 1963, Popular Science reported on the Nobel Prize-winning discovery, and Rosalind Franklin⁠—the woman who was left out of the accolades.

In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be ...

Caption In the DNA fiber assay used in this study, cells labeled with IdU (green) and CldU (red) nucleotide analogs were sorted into substages of S phase before being subjected to the DNA fiber ...

The crystal structure of human RXRα–LXRβ heterodimer bound to its cognate DNA element, with agonists and a coactivator peptide, is now solved. The heterodimer shows an X-shaped organization ...

Cell biologists and chemists reveal how viral DNA traffics in human cells. They have developed a new method to generate virus particles containing labeled viral DNA genomes. This allowed them to ...

DNA, the hereditary material in living organisms, encodes genetic instructions for development and function. We explore its structure, replication, and role in biotechnology.

Scientists have deciphered the three-dimensional structure of the human genome, paving the way for new insights into genomic function and expanding our understanding of how cellular DNA folds at ...

When we think of the structure of DNA, the image that most likely comes to mind is that of the iconic double helix. This shape was identified in 1953 as DNA's most common form, and while other ...