Early endosomes mature into late endosomes that subsequently fuse with lysosomes. Recycling endosomes are a sub-compartment of early endosomes that return material to the plasma membrane.

Materials marked for degradation are passed to late endosomes and eventually to lysosomes, where they are fully broken down. The transition from early endosomes to late endosomes involves a ...

More information: Marine Bretou et al, Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites ...