The apparent benefits at 2 years observed in the nonrandomized ALT-FLOW study pave the way for a sham-controlled trial.

However, in a subgroup of patients with left atrium enlargement ... "This ablation should be performed only in cases of ...

Secondary mitral regurgitation occurs when left atrial or left ventricular remodeling and dilation leads to mitral valve annular enlargement that prevents effective leaflet coaptation. There are ...