"Down the line, a better understanding of protein-lipid interactions could help researchers find new therapeutic targets for a wide range of metabolic diseases, including Barth syndrome," says ...

Fatty acids function both as an energy source and as metabolic signalling molecules and affect many vital processes. This complexity combined with the chemical characteristics of lipids present ...

Lipids are hydrophobic or amphiphilic small ... These studies provide key structural insights into the molecular defects linked to familial hypercholesterolaemia and open exciting avenues for ...

We have previously shown that several antipsychotic and antidepressant drugs increase lipid biosynthesis through activation of the Sterol Regulatory Element-Binding Protein (SREBP) transcription ...

Targeting efflux of lipids from the liver is an alluring pharmacological objective. Pharmacological inhibition of microsomal triglyceride transfer protein is highly efficacious at lowering LDL-C ...