View Full Profile. Learn about our Editorial Policies. The discovery of the interstitium in 2018 made waves, with many questioning whether scientists had discovered a new organ. 1 “It's actually not ...

Negative-pressure pulmonary edema (NPPE) occurs when a large, negative intrathoracic pressure is generated against an obstructed upper airway, causing fluid to shift into the lung interstitium.

In 2018, the same research team demonstrated the existence of these fluid-filled spaces, which they dubbed the interstitium, challenging conventional wisdom that the space between cells is dense ...