The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...

More recently, in a metastatic mouse melanoma model, B 16 /F 10, we have observed elimination of the lung metastases, when the targeted wt p53 liposomes were systemically delivered in combination ...

One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal role in ensuring that your cells grow, divide and die in an orderly fashion.

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.

No one really understands why activation of the tumor suppressor p53 sometimes leads to cell-cycle arrest and sometimes induces an apoptotic program. It has been proposed that post-translational ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

The stem cell signal Msi2 plays a dual role in lung cancer, acting as a signal that is not only essential for initiation, but also for propagation of the tumor.

Ubiquitin-specific protease 7 (USP7) is involved in DNA repair and cell cycle progression and, due to its control over the ubiquitination of key proteins, may impact oncogenes like MDM2 and c-Myc, as ...

Navtemadlin is an MDM2 inhibitor that can help to kill cancer cells by boosting the activity of p53, a protein that controls cell growth and induces cell death in response to DNA damage.

Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature. 2010;468(7323):572-5. 5. Morris JPt, Yashinskie JJ, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS ...