About 85 percent of dogs with blastomycosis have a lung infection, but it can spread throughout the body and affect the brain, eyes, lymph nodes, bones, and skin. When it spreads, it can cause ...

It involves the lymph system, most commonly throughout the body, and can invade anywhere. Diagnosing lymphoma when the dog has peripherally palpable lymph nodes is relatively straightforward.

The most common sign of multicentric lymphoma in dogs is firm, enlarged, non-painful lymph nodes. An affected lymph node will feel hard, rubbery and like a lump under the dog’s skin.