Then, depending on the stimuli that initiated the autophagy process, the cargo is either degraded or recycled. In 2004, fifty years after Novikoff and de Duve observed lysosomes under the electron ...

"Lysosomes are organelles that are involved in autophagy, a cellular process that cleans up damaged material, almost like a ...

The autophagosomes, autolysosomes and lysosomes can be considered as different stages of the cellular recycling process. Therefore, when cells notice they have too much "junk" inside, autophagy ...

ALR, autophagic lysosome reformation; ER, endoplasmic reticulum; ESCRT, endosomal sorting complexes required for transport; TFEB, transcription factor EB. Credit By Wen-Xing Ding, Xiaowen Ma ...

While studying how p47 influences autophagy, the team zeroed in on lysosomes, organelles that supply the digestive enzymes needed to recycle waste. 6 In p47’s absence, Guan and his team observed an ...

Autophagy is an evolutionally conserved cellular process to maintain homeostasis in eukaryotes. Double-membraned autophagosomes engulf cytosolic cargoes to deliver them to the lysosome or vacuole for ...

Among these, the transcription factors EB (TFEB) and E3 (TFE3) caught Tan’s attention, because their activation coincided with genes that increased lysosome production. TFEB is also an ancient ...

The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis. Cell biologist Michael Overholtzer explores genes that make ...

They consist of the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, peroxisomes, etc., each of which has a different function. *6 Autophagosome An organelle that mediates ...

Then, depending on the stimuli that initiated the autophagy process, the cargo is either degraded or recycled. In 2004, fifty years after Novikoff and de Duve observed lysosomes under the electron ...