Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged ...

Scientists have uncovered more than 20 genes whose mutations cause familial forms of Parkinson's disease. One of these genes ...

The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a ...

Any proteins that are destined for a lysosome are delivered to the lysosome interior when the vesicle that carries them fuses with the lysosomal membrane and joins its contents. In contrast ...

He labeled proteins and followed them in their journey ... they established that after autophagosomes form, they fuse to the lysosomal membrane to form a structure known as the autolysosome ...

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...

Genes associated with lysosomal dysfunction increase the risk of Parkinson ... The key lies in the Commander complex, ...

Using a version of the enzyme which localizes to lysosomes and a chemical known to puncture the lysosomal membrane, he was able to biotinylate all the proteins surrounding the damaged organelle. Tan ...

2 Lysosomal degradation of the ADC releases the cytotoxic ... s target or by increasing the expression of ATP-binding cassette transporters. 1 These membrane proteins enable the cell to actively pump ...